The Fitzpatrick Institute for Photonics (FIP)

Friday, June 6, 2008 ~ FCIEMAS Schiciano Auditorium B~ 1:00 -2:00pm
*Special Day & Time*

Eric Seibel, Ph.D. Research Associate Professor Mechanical Engineering Adjunct Bioengineering Human Photonics Laboratory University of Washington

ITUNES podcast of Seminar 
(For Duke Faculty & Students only - must have Duke Net ID for access)
http://lectopia.oit.duke.edu/ilectures/ilectures.lasso?ut=446&id=8797


Biophotonics - Early Detection & Diagnosis of Cancer
A renaissance is occurring in the field of biophotonics and especially in the application of early detection and diagnosis of cancer.  In this area, two new optical imaging technologies developed at the University of Washington will be reviewed, (1) scanning fiber endoscopy (SFE) and (2) 3D cytological analysis using optical projection tomography.  SFE uses a singlemode optical fiber carrying RGB laser light that is scanned at its mechanical resonance to generate high resolution and wide field of view images at video rates.  Since the fiber scanner is sub-millimeter in size, prototype ultrathin and flexible endoscopes are being tested at unprecedented performance.  Additional capabilities that are afforded by scanning high-quality laser light, such as real-time zooming with enhanced spectral contrast, fluorescence imaging in 2D and 3D, and optical spectroscopies for disease detection and future treatment.  3D cytological microscopes have been designed to image cells in the same manner as x-ray CT for human anatomical imaging.  But instead of using x-rays, visible light is scanned through the nucleus as the cell is being rotated to form psuedoprojections from the attenuated light transmission.  3D reconstructions of single cells stained with hematoxylin allow 3D cytological analysis with the goal of increasing sensitivity of cancer diagnosis.

Biography:   Dr. Seibel received undergraduate and master degrees in Mechanical Engineering from Cornell University and University of California, Berkeley, respectively. After working 4 years in the medical (ophthalmic) device industry, Eric designed and developed laser scanning microscopes for live tissue imaging for his doctorate from the University of Washington's Department of Bioengineering in 1996. As a Research Scientist at the Human Interface Technology Lab, UW, Eric invented the scanning fiber endoscope which has received funding from WTC, NCI, NSF, and PENTAX Corporation. Since 2001 as research faculty at UW, Eric has co-developed an optical projection tomography microscope with VisionGate Inc. with funding from WTC and NCI. Currently, Dr. Seibel is a Research Associate Professor in the Department of Mechanical Engineering, adjunct in Bioengineering, and Director of the Human Photonics Lab at UW.