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“Biosensors Based on Functional Nanomaterials”
The emergence of nanotechnology is opening new horizons for the application of nanoparticles in biosensors and bioassays. In this presentation, I will discuss the recent progress at PNNL on biosensors development based on functional nanomaterials. Sensitive electrochemical immunoassays based on nanoparticle labels have been developed for the detection of protein biomarkers. The use of functional quantum dots, carbon nanotubes, marker loaded protein-cage, and silica nanoparticles as labels for signal amplification will be discussed. By combination with disposable test strip technique, the nanoparticles-based biosensors is simple, selective, and reproducible for sensitive detecting biomarkers of response to environmental stressors. A low detection limit has been achieved through signal amplification by functionalized nanoparticle labels. The work demonstrates the feasibility of developing an inexpensive, sensitive, and portable device for detection of different protein biomarkers.
Yuehe Lin joined Pacific Northwest National Laboratory (PNNL) as a research scientist in 1997. He was promoted to Chief Scientist in 2004. Recently, he has been actively working in the nanotechnology area, particularly in the development of new BioMEMS and nanobioelectronic devices for diagnosis and drug delivery. His other research activities include developing integrated microanalytical systems for environmental and biomedical analysis and synthesizing functional nanomaterials for biosensing, fuel cell, and water-treatment applications.
Dr. Lin has over 170 peer-reviewed publications and 10 patents. He is the co-editor of two books: the Handbook of Electrochemical Nanotechnology and Encyclopedia of Microfluidics and Nanofluidics. He also serves as the North American Editor for the Journal of Nanoscience and Nanotechnology and is a member of the editorial advisory board of 15 other international journals.
Dr. Lin received his Ph.D. in Environmental Chemistry from the University of Idaho in 1997 and also received a Ph.D. in Analytical Chemistry from Xiamen University, Xiamen, China, in 1991. He received his B.S. degree in Chemistry from Peking University, Beijing, China, in 1984.
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